Major Research Areas
Molecular Pharmacology & Chemistry
Office Phone:646-422-4322
E-mail:scardinp@mskcc.org
Lab Phone:646-422-4322
Lab Fax:212-988-0874

The Urologic Oncologic Research Laboratory is devoted to translational studies of the biology of the four types of genitourinary cancer -- prostate, bladder, kidney, and testis.  Specifically, our research focuses on cell-cycle and apoptotic regulatory systems; the identification and validation of novel tissue markers of progression; the design and testing of strategies for accurate and efficient sampling of cancer from the prostate; and the development of new models of progression and decision-analysis using medical informatics.

In collaboration with other institutions, such as Cornell University and Stanford University, our investigators are designing an optical imaging system and new contrast agent (a monoclonal antibody linked to a fluorophore) to image a small number of prostate cancer cells in vivo in real time.

Composite of 206 prostatectomy specimens
Composite of 206 Prostatectomy Specimens. The brightness in this anterior view of 206 prostatectomy specimens is associated with a higher probability of prostate cancer (see Project: Patterns of Growth of Cancer within the Prostate).

In collaboration with other investigators at Memorial Sloan-Kettering Cancer Center, members of the Department of Urology are investigating:

  • prostate-specific circulating and tissue markers in human prostate cancer (Hans Lilja, MD, PhD);
  • the genetic modification of human T cells to target prostate-specific membrane antigen (PSMA) in human prostate cancer (laboratory of Michel Sadelain, MD, PhD);
  • examining the expression of PSMA in prostate and other cancers and the neovasculature of a wide range of cancers (Victor Reuter, MD, Department of Pathology);
  • validating the prognostic significance of p27 in human prostate cancer samples (Carlos Cordon-Cardo, MD, PhD, Division of Molecular Pathology).

These collaborations also involve other institutions, greatly benefiting the young investigators who are trained here.


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