Projects

We have described how stem cells derived from both rat and human midbrain can be proliferated and differentiated into dopamine neurons in culture.

Mouse Embryonic Stem Cells - The generation of unlimited numbers of dopamine neurons from mouse embryonic stem cells can be achieved in a multi-step differentiation protocol, allowing the sequential generation of embryonic stem cells, embryoid bodies, early ectodermal cells, proliferating CNS precursors, and differentiated neurons and glia. Human Embryonic Stem Cells - We have developed protocols for the efficient generation of neural progeny from various human ES cell lines.

Therapeutic cloning offers a strategy for generating autologous (genetically identical to graft recipient) cells for transplantation therapy. Parthenogenesis allows the generation of pluripotent ES-like stem cells via activation of an unfertilized egg cell.